UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G


                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                             (AMENDMENT NO.      )*


                                  ArQule, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.01 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   00004269E1
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                              
                               Page 1 of 22 Pages



CUSIP No. 00004269E1                                          Page 2 of 22 Pages

- ------- ------------------------------------------------------------------------
1       NAME OF REPORTING PERSON
        S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Atlas Venture Fund II, L.P.

- ------- ------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                               (a) [  ]
                                                               (b) [  ]

- ------- ------------------------------------------------------------------------
3       SEC USE ONLY


- ------- ------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware Limited Partnership

- ------- ------------------------------------------------------------------------
                                 5      SOLE VOTING POWER
NUMBER OF                                    0 shares
SHARES
                                 ------ ----------------------------------------
BENEFICIALLY OWNED BY            6      SHARED VOTING POWER
EACH                                         1,355,738 shares

                                 ------ ----------------------------------------
REPORTING                        7      SOLE DISPOSITIVE POWER
PERSON                                       0 shares
WITH
                                 ------ ----------------------------------------
                                 8      SHARED DISPOSITIVE POWER
                                             1,355,738 shares

- ------- ------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            1,355,738 shares

- ------- ------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                      [  ]
- ------- ------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
             13.8%

- ------- ------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

             PN

- ------- ------------------------------------------------------------------------


                               Page 2 of 22 Pages

                               

CUSIP No. 00004269E1                                          Page 3 of 22 Pages

- ------- ------------------------------------------------------------------------
1       NAME OF REPORTING PERSON
        S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Atlas Venture Associates II, L.P.

- ------- ------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                               (a)  [  ]
                                                               (b)  [  ]

- ------- ------------------------------------------------------------------------
3       SEC USE ONLY


- ------- ------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware Limited Partnership

- ------- ------------------------------------------------------------------------
                                 5      SOLE VOTING POWER
NUMBER OF                                    0 shares
SHARES
                                 ------ ----------------------------------------
BENEFICIALLY OWNED BY            6      SHARED VOTING POWER
EACH                                         1,355,738 shares

                                 ------ ----------------------------------------
REPORTING                        7      SOLE DISPOSITIVE POWER
PERSON                                       0 shares
WITH
                                 ------ ----------------------------------------
                                 8      SHARED DISPOSITIVE POWER
                                             1,355,738 shares

- ------- ------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            1,355,738 shares

- ------- ------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                      [  ]
- ------- ------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
             13.8%

- ------- ------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

             PN

- ------- ------------------------------------------------------------------------



                               Page 3 of 22 Pages


CUSIP No. 00004269E1                                          Page 4 of 22 Pages

- ------- ------------------------------------------------------------------------
1       NAME OF REPORTING PERSON
        S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Christopher J. Spray

- ------- ------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                    (a)  [  ]
                                                                    (b)  [  ]

- ------- ------------------------------------------------------------------------
3       SEC USE ONLY


- ------- ------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States

- -------------------------------- ------ ----------------------------------------
                                 5      SOLE VOTING POWER
NUMBER OF                                    0 shares
SHARES
                                 ------ ----------------------------------------
BENEFICIALLY OWNED BY            6      SHARED VOTING POWER
EACH                                         931,558 shares

                                 ------ ----------------------------------------
REPORTING                        7      SOLE DISPOSITIVE POWER
PERSON                                       0 shares
WITH
                                 ------ ----------------------------------------
                                 8      SHARED DISPOSITIVE POWER
                                             931,558 shares

- -------------------------------- ------ ----------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            931,558 shares

- ------- ------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                      [  ]
- ------- ------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
             9.5%

- ------- ------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

             IN

- ------- ------------------------------------------------------------------------


                               Page 4 of 22 pages


CUSIP No. 00004269E1                                          Page 5 of 22 Pages

- ------- ------------------------------------------------------------------------
1       NAME OF REPORTING PERSON
        S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Barry Fidelman

- ------- ------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                    (a) [  ]
                                                                    (b) [  ]

- ------- ------------------------------------------------------------------------
3       SEC USE ONLY


- ------- ------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States

- -------------------------------- ------ ----------------------------------------
                                 5      SOLE VOTING POWER
NUMBER OF                                    0 shares
SHARES
                                 ------ ----------------------------------------
BENEFICIALLY OWNED BY            6      SHARED VOTING POWER
EACH                                         931,558 shares

                                 ------ ----------------------------------------
REPORTING                        7      SOLE DISPOSITIVE POWER
PERSON                                       0 shares
WITH
                                 ------ ----------------------------------------
                                 8      SHARED DISPOSITIVE POWER
                                             931,558 shares

- ------- ------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            931,558 shares

- ------- ------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                      [  ]
- ------- ------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
             9.5%

- ------- ------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

             IN

- ------- ------------------------------------------------------------------------


                               Page 5 of 22 Pages


CUSIP No. 00004269E1                                          Page 6 of 22 Pages

- ------- ------------------------------------------------------------------------
1       NAME OF REPORTING PERSON
        S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Allan Ferguson

- ------- ------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                    (a) [  ]
                                                                    (b) [  ]

- ------- ------------------------------------------------------------------------
3       SEC USE ONLY


- ------- ------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States

- ------- ------------------------------------------------------------------------
                                 5      SOLE VOTING POWER
NUMBER OF                                    0 shares
SHARES
                                 ------ ----------------------------------------
BENEFICIALLY OWNED BY            6      SHARED VOTING POWER
EACH                                         931,558 shares

                                 ------ ----------------------------------------
REPORTING                        7      SOLE DISPOSITIVE POWER
PERSON                                       0 shares
WITH
                                 ------ ----------------------------------------
                                 8      SHARED DISPOSITIVE POWER
                                             931,558 shares

- ------- ------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            931,558 shares

- ------- ------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                      [  ]
- ------- ------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
             9.5%

- ------- ------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

             IN

- ------- ------------------------------------------------------------------------


                               Page 6 of 22 pages



CUSIP No. 00004269E1                                          Page 7 of 22 Pages

- ------- ------------------------------------------------------------------------
1       NAME OF REPORTING PERSON
        S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Jean-Francois Formela

- ------- ------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                    (a) [  ]
                                                                    (b) [  ]

- ------- ------------------------------------------------------------------------
3       SEC USE ONLY


- ------- ------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

             France

- ------- ------------------------------------------------------------------------
                                 5      SOLE VOTING POWER
NUMBER OF                                    0 shares
SHARES
                                 ------ ----------------------------------------
BENEFICIALLY OWNED BY            6      SHARED VOTING POWER
EACH                                         931,558 shares

                                 ------ ----------------------------------------
REPORTING                        7      SOLE DISPOSITIVE POWER
PERSON                                       0 shares
WITH
                                 ------ ----------------------------------------
                                 8      SHARED DISPOSITIVE POWER
                                             931,558 shares

- ------- ------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            931,558 shares

- ------- ------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                      [  ]
- ------- ------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
             9.5%

- ------- ------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

             IN

- ------- ------------------------------------------------------------------------



                               Page 7 of 22 Pages


CUSIP No. 00004269E1                                          Page 8 of 22 Pages

- ------- ------------------------------------------------------------------------
1       NAME OF REPORTING PERSON
        S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Atlas Venture Europe Fund B.V.

- ------- ------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                    (a) [  ]
                                                                    (b) [  ]

- ------- ------------------------------------------------------------------------
3       SEC USE ONLY


- ------- ------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

             The Netherlands

- ------- ------------------------------------------------------------------------
                                 5      SOLE VOTING POWER
NUMBER OF                                    0 shares
SHARES
                                 ------ ----------------------------------------
BENEFICIALLY OWNED BY            6      SHARED VOTING POWER
EACH                                         1,355,738 shares

                                 ------ ----------------------------------------
REPORTING                        7      SOLE DISPOSITIVE POWER
PERSON                                       0 shares
WITH
                                 ------ ----------------------------------------
                                 8      SHARED DISPOSITIVE POWER
                                             1,355,738 shares

- ------- ------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            1,355,738 shares

- ------- ------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                      [  ]
- ------- ------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
             13.8%

- ------- ------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

             CO

- ------- ------------------------------------------------------------------------



                               Page 8 of 22 pages


CUSIP No. 00004269E1                                          Page 9 of 22 Pages

- ------- ------------------------------------------------------------------------
1       NAME OF REPORTING PERSON
        S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             Atlas InvesteringsGroep N.V.

- ------- ------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                    (a) [  ]
                                                                    (b) [  ]

- ------- ------------------------------------------------------------------------
3       SEC USE ONLY


- ------- ------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

             The Netherlands

- ------- ------------------------------------------------------------------------
                                 5      SOLE VOTING POWER
NUMBER OF                                    0 shares
SHARES
                                 ------ ----------------------------------------
BENEFICIALLY OWNED BY            6      SHARED VOTING POWER
EACH                                         1,355,738 shares

                                 ------ ----------------------------------------
REPORTING                        7      SOLE DISPOSITIVE POWER
PERSON                                       0 shares
WITH
                                 ------ ----------------------------------------
                                 8      SHARED DISPOSITIVE POWER
                                             1,355,738 shares

- ------- ------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            1,355,738 shares

- ------- ------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                      [  ]
- ------- ------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
             13.8%

- ------- ------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

             CO

- ------- ------------------------------------------------------------------------


                               Page 9 of 22 Pages



                                  Schedule 13G

Item 1(a).        Name of Issuer: ArQule, Inc.

Item 1(b).        Address of Issuer's Principal  Executive  Offices:  200 Boston
                  Avenue, Medford, Massachusetts 02155

Item 2(a).        Names of Persons  Filing:  Atlas Venture Fund II, L.P.,  Atlas
                  Venture  Associates  II,  L.P.,  Christopher  J. Spray,  Barry
                  Fidelman, Allan Ferguson, Jean-Francois Formela, Atlas Venture
                  Europe Fund B.V. and Atlas InvesteringsGroep N.V.

                  Atlas Venture  Associates II, L.P. is the sole general partner
                  of  Atlas  Venture  Fund II,  L.P.  Messrs.  Spray,  Fidelman,
                  Ferguson and Formela are the  individual  general  partners of
                  Atlas Venture Associates II, L.P. Atlas InvesteringsGroep N.V.
                  is the sole shareholder of Atlas Venture Europe Fund B.V.

Item 2(b).        Address of Principal  Business Office or, if None,  Residence:
                  The address of the principal  business office of Atlas Venture
                  Fund II, L.P.,  Atlas Venture  Associates II, L.P. and Messrs.
                  Spray,  Fidelman,  Ferguson and Formela is Atlas Venture,  222
                  Berkeley Street,  Boston,  Massachusetts 02116. The address of
                  the principal  business  office of Atlas  Venture  Europe Fund
                  B.V.    and   Atlas    InvesteringsGroep    N.V.    is   Atlas
                  InvesteringsGroep  N.V.,  Naarderpoort 1, 1411 MA Naarden, The
                  Netherlands.

Item 2(c).        Citizenship:  Atlas  Venture Fund II, L.P.  and Atlas  Venture
                  Associates II, L.P. are each a limited  partnership  organized
                  under  the  laws of the  State  of  Delaware.  Messrs.  Spray,
                  Fidelman and Ferguson are citizens of the United  States.  Mr.
                  Formela is a citizen of France. Atlas Venture Europe Fund B.V.
                  and  Atlas  InvesteringsGroep  N.V.  are  each  a  corporation
                  organized under the laws of The Netherlands.

Item 2(d).        Title of Class of Securities:  Common Stock, $.01 par value.

Item 2(e).        CUSIP Number:  00004269E1

Item 3.           If this  statement  is filed  pursuant to Rules  13d-1(b),  or
                  13d-2(b), check whether the person filing is a:
                 
                  (a)      [   ]    Broker or Dealer registered under Section 15
                                    of the Securities  Exchange Act of 1934 (the
                                    "Act").

                  (b)      [   ]    Bank as defined  in  Section  3(a)(6) of the
                                    Act.

                  (c)      [   ]    Insurance  Company  as  defined  in  Section
                                    3(a)(19) of the Act.

                  (d)      [   ]    Investment  Company registered under Section
                                    8 of the Investment Company Act of 1940.



                              Page 10 of 22 Pages



                  (e)      [   ]    Investment  Adviser registered under Section
                                    203 of the Investment Advisers Act of 1940.

                  (f)      [   ]    Employee Benefit Plan, Pension Fund which is
                                    subject to the  provisions  of the  Employee
                                    Retirement  Income  Security  Act of 1974 or
                                    Endowment Fund; see Rule  13d-1(b)(1)(ii)(F)
                                    of the Act.

                  (g)      [   ]    Parent Holding  Company,  in accordance with
                                    Rule 13d-1(b)(ii)(G) of the Act.

                  (h)      [   ]    Group,     in    accordance     with    Rule
                                    13d-1(b)(1)(ii)(H) of the Act.

                  Not Applicable.

Item 4.  Ownership.

         (a)      Amount Beneficially Owned:

                  Each of Atlas Venture Fund II, L.P., Atlas Venture  Associates
                  II,   L.P.,   Atlas   Venture   Europe  Fund  B.V.  and  Atlas
                  InvesteringsGroep   N.V.   (individually   an   "Entity"   and
                  collectively the "Entities") may be deemed to own beneficially
                  1,355,738 shares of Common Stock as of December 31, 1996. Each
                  of Messrs. Spray, Fidelman, Ferguson and Formela may be deemed
                  to own  beneficially  931,558  shares  of  Common  Stock as of
                  December 31, 1996.

                  As of December  31, 1996,  Atlas  Venture Fund II, L.P. is the
                  record  owner of  931,558  shares  of  Common  Stock and Atlas
                  Venture Europe Fund B.V. is the record owner of 424,180 shares
                  of Common  Stock  (referred  to as the  "Record  Shares").  By
                  virtue of the affiliate relationships among the Entities, each
                  Entity  may be deemed to own  beneficially  all of the  Record
                  Shares.  Hence,  each Entity may be deemed to own beneficially
                  1,355,738  shares  of Common  Stock.  In their  capacities  as
                  individual  general  partners of Atlas Venture  Associates II,
                  L.P., each of Messrs.  Spray,  Fidelman,  Ferguson and Formela
                  may be deemed  to own  beneficially  931,558  shares of Common
                  Stock.

         (b)      Percent of Class:

                  Atlas Venture Fund II, L.P.                    13.8%
                  Atlas Venture Associates II, L.P.              13.8%
                  Christopher J. Spray                           9.5%
                  Barry Fidelman                                 9.5%
                  Allan Ferguson                                 9.5%
                  Jean-Francois Formela                          9.5%
                  Atlas Venture Europe Fund B.V.                 13.8%
                  Atlas InvesteringsGroep N.V.                   13.8%



                               Page 11 of 22 Pages



         The foregoing  percentages are calculated based on the 9,851,487 shares
         of Common Stock  reported to be  outstanding  in the  Prospectus  dated
         October 16, 1996 of ArQule, Inc.

         (c)      Number of shares as to which such person has:

                  (i) sole power to vote or to direct the vote:

                       0 shares for each reporting person

                  (ii) shared power to vote or to direct the vote:

                  Atlas Venture Fund II, L.P.               1,355,738 shares
                  Atlas Venture Associates II, L.P.         1,355,738 shares
                  Christopher J. Spray                        931,558 shares
                  Barry Fidelman                              931,558 shares
                  Allan Ferguson                              931,558 shares
                  Jean-Francois Formela                       931,558 shares
                  Atlas Venture Europe Fund B.V.            1,355,738 shares
                  Atlas InvesteringsGroep N.V.              1,355,738 shares

                  (iii) sole power to dispose or to direct the dispositions of:

                        0 shares for each reporting person

                  (iv) shared power to dispose or to direct the disposition of:

                  Atlas Venture Fund II, L.P.               1,355,738 shares
                  Atlas Venture Associates II, L.P.         1,355,738 shares
                  Christopher J. Spray                        931,558 shares
                  Barry Fidelman                              931,558 shares
                  Allan Ferguson                              931,558 shares
                  Jean-Francois Formela                       931,558 shares
                  Atlas Venture Europe Fund B.V.            1,355,738 shares
                  Atlas InvesteringsGroep N.V.              1,355,738 shares

         Each of the reporting persons expressly disclaims  beneficial ownership
         of any shares of Common  Stock of ArQule,  Inc.,  except in the case of
         (i) Atlas  Venture Fund II, L.P. for the 931,558  shares which it holds
         of record and (ii)  Atlas  Venture  Europe  Fund B.V.  for the  424,180
         shares which it holds of record.

Item 5.  Ownership of Five Percent or Less of a Class.

         Not Applicable

Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

         Not Applicable.



                               Page 12 of 22 Pages



Item 7.  Identification  and Classification of the Subsidiary Which Acquired the
         Security Being Reported on by the Parent Holding Company.

         Not Applicable.

Item 8.  Identification and Classification of Members of the Group.

         Not Applicable.  The reporting persons expressly disclaim membership in
         a "group" as defined in Rule 13d-1(b)(ii)(H).

Item 9.  Notice of Dissolution of Group.

         Not Applicable.

Item 10.  Certification.

         Not Applicable. This statement on Schedule 13G is not filed pursuant to
         Rule 13d-1(b).




                               Page 13 of 22 Pages




                                   SIGNATURES
                                   ----------

         After  reasonable  inquiry and to the best of our knowledge and belief,
we certify that the  information  set forth in this statement is true,  complete
and correct. We also hereby agree to file this statement jointly pursuant to the
Agreement listed on Exhibit 1 hereto.

Dated:  February 7, 1997

ATLAS VENTURE FUND II, L.P.                         ATLAS INVESTERINGSGROEP N.V.

By:   Atlas Venture Associates II, L.P.
                                                     By:             *          
                                                        ------------------------
                                                              Michiel de Haan,
                                                              Managing Director
By:         *
   --------------------------
      Christopher J. Spray,
      General Partner                                                *
                                                        ------------------------
                                                        Christopher J. Spray
ATLAS VENTURE ASSOCIATES II, L.P.

                                                                     *
                                                        ------------------------
By:         *                                           Barry Fidelman
   --------------------------
      Christopher J. Spray,
      General Partner
                                                                     *
                                                        ------------------------
                                                        Allan Ferguson
ATLAS VENTURE EUROPE FUND B.V.

By:   Atlas InvesteringsGroep N.V.                                   *
                                                        ------------------------
                                                        Jean-Francois Formela

By:         *
   --------------------------
      Michiel de Haan,
      Managing Director



*   The  undersigned  attorney-in-fact,  by signing her name below,  does hereby
    sign this  statement  on behalf of the above  indicated  filers  pursuant to
    Powers of Attorney filed hereto as Exhibit 2.


     /s/ Jeanne Larkin Henry
     ---------------------------
     Jeanne Larkin Henry
     Attorney-in-fact



                               Page 14 of 22 Pages




                                                                      Exhibit 1
                                    AGREEMENT

         Pursuant to Rule 13d-1(f)(1) under the Securities Exchange Act of 1934,
the undersigned hereby agree that only one statement  containing the information
required by Schedule 13G need be filed with respect to the  ownership by each of
the undersigned of shares of Common Stock of ArQule, Inc.

         This agreement may be executed in any number of  counterparts,  each of
which shall be deemed an original.

         EXECUTED this 7th day of February, 1997.


ATLAS VENTURE FUND II, L.P.                         ATLAS INVESTERINGSGROEP N.V.

By:   Atlas Venture Associates II, L.P.
                                                     By:             *          
                                                        ------------------------
                                                              Michael de Haan,
                                                              Managing Director
By:         *
   --------------------------
      Christopher J. Spray,
      General Partner                                                *
                                                        ------------------------
                                                        Christopher J. Spray
ATLAS VENTURE ASSOCIATES II, L.P.

                                                                     *
                                                        ------------------------
By:         *                                           Barry Fidelman
   --------------------------
      Christopher J. Spray,
      General Partner
                                                                     *
                                                        ------------------------
                                                        Allan Ferguson
ATLAS VENTURE EUROPE FUND B.V.

By:   Atlas InvesteringsGroep N.V.                                   *
                                                        ------------------------
                                                        Jean-Francois Formela

By:         *
   --------------------------
      Michiel de Haan,
      Managing Director



*   The  undersigned  attorney-in-fact,  by signing her name below,  does hereby
    sign this  statement  on behalf of the above  indicated  filers  pursuant to
    Powers of Attorney filed hereto as Exhibit 2.


     /s/ Jeanne Larkin Henry
     ---------------------------
     Jeanne Larkin Henry
     Attorney-in-fact


                               Page 15 of 22 Pages



                                POWER OF ATTORNEY


         KNOW  ALL MEN BY THESE  PRESENTS,  that  each  person  whose  signature
appears below hereby  constitutes  and appoints each and any of  Christopher  J.
Spray and Jeanne  Larkin Henry his true and lawful  attorney-in-fact  and agent,
with full power of  substitution  and  resubstitution,  for him and in his name,
place and stead,  in any and all  capacities  (until revoked in writing) to sign
any and all instruments,  certificates and documents  required to be executed on
behalf of  himself  individually  or on  behalf of each or any of Atlas  Venture
Fund,  L.P., Atlas Venture  Associates,  L.P., Atlas Venture Partners III, B.V.,
Atlas Venture Fund II, L.P.,  Atlas Venture  Associates II, L.P.,  Atlas Venture
Europe Fund B.V., Atlas InvesteringsGroep N.V., and Atlas Venture Beheer II B.V.
pursuant  to  sections  13 and 16 of the  Securities  Exchange  Act of 1934,  as
amended  (the  "Exchange  Act"),   and  any  and  all  regulations   promulgated
thereunder,  and to file the  same,  with all  exhibits  thereto,  and any other
documents in connection therewith,  with the Securities and Exchange Commission,
and with any other entity when and if such is mandated by the Exchange Act or by
the By-laws of the National  Association  of Securities  Dealers,  granting unto
said  attorney-in-fact and agent full power and authority to do and perform each
and  every  act and thing  requisite  and  necessary  fully to all  intents  and
purposes as he might or could do in person thereby  ratifying and confirming all
that said  attorney-in-fact  and agent,  or his substitute or  substitutes,  may
lawfully do or cause to be done by virtue hereof.





                  [REMAINDER OF PAGE LEFT BLANK INTENTIONALLY]

                      [SIGNATURE PAGE FOLLOWS IMMEDIATELY]




                               Page 16 of 22 Pages




      IN WITNESS WHEREOF,  this Power of Attorney has been signed as of the 31st
day of January, 1997.



                                      /s/ Christopher J. Spray
                                      ------------------------
                                          Christopher J. Spray


Commonwealth of Massachusetts  )
                               ) ss:
County of Suffolk              )

      On this 31st day of January,  1997,  before me personally came Christopher
J. Spray,  known to me to be the person described and who executed the foregoing
instrument that he acknowledged that he executed the same.


[Notary Seal]                              /s/ Elizabeth  A. LeBlanc
                                           -----------------------------
                                           Notary Public

                                           My commission expires:  July 3, 1998


                               Page 17 of 22 Pages



      IN WITNESS WHEREOF,  this Power of Attorney has been signed as of the 31st
day of January, 1997.



                                           /s/ Barry Fidelman
                                           --------------------------
                                               Barry Fidelman


Commonwealth of Massachusetts )
                              ) ss:
County of Suffolk             )

      On this  31st day of  January,  1997,  before  me  personally  came  Barry
Fidelman,  known to me to be the person described and who executed the foregoing
instrument that he acknowledged that he executed the same.


[Notary Seal]                              /s/ Elizabeth  A. LeBlanc
                                           ----------------------------
                                           Notary Public

                                           My commission expires:  July 3, 1998


                               Page 18 of 22 Pages



      IN WITNESS WHEREOF,  this Power of Attorney has been signed as of the 31st
day of January, 1997.



                                           /s/ Michiel de Haan
                                           -------------------------
                                               Michiel de Haan


Commonwealth of Massachusetts  )
                               ) ss:
County of Suffolk              )

      On this 31st day of January,  1997,  before me personally  came Michiel de
Haan,  known to me to be the person  described  and who executed  the  foregoing
instrument that he acknowledged that he executed the same.


[Notary Seal]                              /s/ Elizabeth  A. LeBlanc
                                           ---------------------------
                                           Notary Public

                                           My commission expires:  July 3, 1998


                               Page 19 of 22 Pages


      IN WITNESS WHEREOF,  this Power of Attorney has been signed as of the 31st
day of January, 1997.



                                           /s/ Evert Smid
                                           ---------------------------
                                               Evert Smid


Commonwealth of Massachusetts  )
                               ) ss:
County of Suffolk              )

      On this 31st day of January,  1997,  before me personally came Evert Smid,
known to me to be the person described and who executed the foregoing instrument
that he acknowledged that he executed the same.


[Notary Seal]                              /s/ Elizabeth  A. LeBlanc
                                           -----------------------------
                                           Notary Public

                                           My commission expires:  July 3, 1998



                               Page 20 of 22 Pages



      IN WITNESS WHEREOF,  this Power of Attorney has been signed as of the 31st
day of January, 1997.



                                           /s/ Allan R. Ferguson
                                           --------------------------
                                               Allan R. Ferguson


Commonwealth of Massachusetts  )
                               ) ss:
County of Suffolk              )

      On this 31st day of  January,  1997,  before me  personally  came Allan R.
Ferguson,  known to me to be the person described and who executed the foregoing
instrument that he acknowledged that he executed the same.


[Notary Seal]                              /s/ Elizabeth  A. LeBlanc
                                           ---------------------------
                                           Notary Public

                                           My commission expires:  July 3, 1998


                               Page 21 of 22 Pages



      IN WITNESS WHEREOF,  this Power of Attorney has been signed as of the 31st
day of January, 1997.



                                           /s/ Jean-Francois Formela
                                           ----------------------------
                                           Jean-Francois Formela


Commonwealth of Massachusetts  )
                               ) ss:
County of Suffolk              )

      On this 31st day of January, 1997, before me personally came Jean-Francois
Formela,  known to me to be the person  described and who executed the foregoing
instrument that he acknowledged that he executed the same.


[Notary Seal]                              /s/ Elizabeth  A. LeBlanc
                                           -------------------------------
                                           Notary Public

                                           My commission expires:  July 3, 1998




                               Page 22 of 22 Pages